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Charles P O'Brien Selected Research

Cocaine-Related Disorders (Cocaine Addiction)

11/2021The Persistent Challenge of Developing Addiction Pharmacotherapies.
10/2015A double blind, placebo controlled trial of modafinil for the treatment of cocaine dependence without co-morbid alcohol dependence.
6/2013Case-control association study of WLS variants in opioid and cocaine addicted populations.
11/2012Neuronal calcium sensor-1 and cocaine addiction: a genetic association study in African-Americans and European Americans.
10/2012A double-blind, placebo-controlled trial of modafinil for cocaine dependence.
6/2012Rational development of addiction pharmacotherapies: successes, failures, and prospects.
2/2012Results of an initial clinical trial of varenicline for the treatment of cocaine dependence.
3/2011A double-blind, placebo-controlled pilot trial of acamprosate for the treatment of cocaine dependence.
4/2010Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence.
10/2009Association analysis between polymorphisms in the dopamine D3 receptor (DRD3) gene and cocaine dependence.
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Charles P O'Brien Research Topics

Disease

30Opioid-Related Disorders (Opiate Addiction)
11/2021 - 07/2002
27Alcoholism (Alcohol Abuse)
10/2015 - 01/2004
25Cocaine-Related Disorders (Cocaine Addiction)
11/2021 - 03/2002
13Substance Withdrawal Syndrome (Withdrawal Symptoms)
01/2021 - 01/2002
12Substance-Related Disorders (Drug Abuse)
01/2018 - 12/2005
6Heroin Dependence (Heroin Abuse)
05/2013 - 06/2004
4Pain (Aches)
01/2019 - 01/2011
3Chronic Pain
01/2019 - 01/2011
3Mental Disorders (Mental Disorder)
01/2018 - 04/2010
2Narcolepsy
10/2015 - 05/2003
2Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder)
08/2013 - 03/2010
2Tobacco Use Disorder (Nicotine Dependence)
08/2013 - 06/2012
2HIV Infections (HIV Infection)
12/2010 - 06/2006
2Infections
07/2003 - 12/2002
1Circadian Rhythm Sleep Disorders (Delayed Sleep Phase Syndrome)
10/2015
1Gambling (Pathological Gambling)
08/2013
1Muscle Spasticity (Spastic)
01/2013
1Depressive Disorder (Melancholia)
03/2010
1Anxiety Disorders (Anxiety Disorder)
03/2010
1Marijuana Use
03/2010
1Hypotension (Low Blood Pressure)
09/2008
1Chronic Disease (Chronic Diseases)
07/2008
1Alcohol-Related Disorders
09/2006
1Disease Progression
07/2003

Drug/Important Bio-Agent (IBA)

36Naltrexone (ReVia)FDA LinkGeneric
01/2019 - 11/2002
19Cocaine (Cocaine HCl)IBA
11/2021 - 01/2002
18Opioid Analgesics (Opioids)IBA
01/2021 - 06/2004
18Pharmaceutical PreparationsIBA
01/2021 - 01/2002
4NicotineFDA Link
11/2021 - 08/2005
4mu Opioid Receptors (mu Opioid Receptor)IBA
03/2016 - 09/2003
4Modafinil (Provigil)FDA Link
10/2015 - 05/2003
4Narcotic Antagonists (Opioid Antagonists)IBA
03/2014 - 06/2006
4Dopamine (Intropin)FDA LinkGeneric
11/2012 - 10/2006
4Methadone (Dolophine)FDA LinkGeneric
12/2010 - 07/2002
3Serotonin (5 Hydroxytryptamine)IBA
10/2011 - 03/2006
3Heroin (Diamorphine)IBA
07/2008 - 08/2005
2Biomarkers (Surrogate Marker)IBA
05/2015 - 03/2014
2Delayed-Action PreparationsIBA
11/2014 - 03/2008
2Opioid Receptors (Opioid Receptor)IBA
03/2014 - 06/2013
2Varenicline (Chantix)FDA Link
12/2013 - 02/2012
2Topiramate (Topamax)FDA LinkGeneric
11/2013 - 09/2004
2Proteins (Proteins, Gene)FDA Link
07/2013 - 11/2012
2Acamprosate (Campral)FDA Link
03/2011 - 06/2009
2Opiate AlkaloidsIBA
12/2010 - 01/2008
2EnzymesIBA
12/2008 - 03/2006
2lofexidineIBA
09/2008 - 01/2008
2Clonidine (ST 155)FDA LinkGeneric
09/2008 - 01/2008
2Disulfiram (Antabuse)FDA Link
05/2008 - 06/2006
2Neurotransmitter Agents (Neurotransmitter)IBA
10/2006 - 03/2006
2preproenkephalinIBA
12/2005 - 11/2005
1insulin receptor-related receptor (IRR)IBA
01/2018
1Therapeutic UsesIBA
03/2014
1Caffeine (No Doz)FDA LinkGeneric
08/2013
1Indicators and Reagents (Reagents)IBA
08/2013
1EndocannabinoidsIBA
07/2013
1Cannabinoid Receptors (Cannabinoid Receptor)IBA
07/2013
1BaclofenFDA LinkGeneric
01/2013
1Dopamine Receptors (Dopamine Receptor)IBA
11/2012
1CalciumIBA
11/2012
1Dopamine AntagonistsIBA
06/2012
1ecopipamIBA
06/2012
1SugarsIBA
04/2012
1gamma-Aminobutyric Acid (GABA)IBA
10/2011
1Corticotropin-Releasing HormoneIBA
10/2011
1EndorphinsIBA
03/2011
1Naloxone Drug Combination BuprenorphineFDA Link
12/2010
1Sertraline (Zoloft)FDA LinkGeneric
06/2010
1Antidepressive Agents (Antidepressants)IBA
06/2010
1Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA
04/2010
1Dopamine D2 Receptors (Dopamine D2 Receptor)IBA
04/2010
1Illicit Drugs (Recreational Drugs)IBA
03/2010
1Dopamine D3 ReceptorsIBA
10/2009
1Nerve Growth Factors (Neurotrophins)IBA
04/2009
1Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA
12/2008
1DNA (Deoxyribonucleic Acid)IBA
10/2008
1Amphetamine (Amfetamine)FDA LinkGeneric
08/2008
1Buprenorphine (Subutex)FDA LinkGeneric
07/2008
1Antipsychotic Agents (Antipsychotics)IBA
08/2007
1Quetiapine Fumarate (Seroquel)FDA Link
08/2007
1Fluoxetine (Prozac)FDA LinkGeneric
12/2006
1Propranolol (Inderal)FDA LinkGeneric
11/2006
1Amantadine (Aman)FDA LinkGeneric
11/2006
1Glutamine (L-Glutamine)FDA Link
10/2006
1Biological ProductsIBA
09/2006
1AmidesIBA
06/2006
1beta-Endorphin (Endorphin, beta)IBA
06/2006
1Ether (Diethyl Ether)IBA
06/2006
1Tryptophan (L-Tryptophan)FDA Link
03/2006
1Interferon-alpha (Interferon Alfa)IBA
07/2003
1Olanzapine (Zyprexa)FDA Link
06/2003
1CCR5 Receptors (CCR5 Receptor)IBA
12/2002
1CC ChemokinesIBA
12/2002
1Ethanol (Ethyl Alcohol)IBA
11/2002
1N-Methylaspartate (NMDA)IBA
07/2002

Therapy/Procedure

9Therapeutics
11/2021 - 07/2002
5Injections
03/2016 - 10/2005
3Secondary Prevention
02/2018 - 03/2015
3Drug Therapy (Chemotherapy)
02/2018 - 01/2013
1Opiate Substitution Treatment
03/2016
1Liver Transplantation
10/2004